![]() ![]() Representation for depicting long term changes and exploring Ways of information representation in strategic decision making Information, capturing of "flow" and sequence of the design process. "time-splicing" - synchronisation of asynchronous work Topic suggestionsīridging the physical-digital divide for distributed teams To talking more with you about this in Potsdam. Grants, so that we can maximize both the relevance to design thinkingĪnd the participation of Stanford and HPI faculty. These people would receive funding, but see this listing primarily asĪn opportunity to better focus the statement of research topic for the To gauge the interest in the research and get a better sense of the ![]() Enhanced expression of Atg5, AIF and caspase genes coupled with the appearance of cell death symptoms indicate parasitism-induced activation of genetic machinery to modulate cell death events in the epithelium, which was hither to unknown in invertebrate systems.And I sent a message to a number of faculty with interests in design, Activation of Atg5, AIF and caspase genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to the macroparasitism. On the other hand, in control, caspase expression showed positive correlation with AIF expression indicative of regulated expression in normal larval epithelium, which was absent after infection. Expression of AIF showed negative correlation with that of Atg5 after the infection. Atg5 showed early upregulation in association with signs of autophagy whereas AIF showed late upregulation in association with DNA condensation and fragmentation. Genes encoding these proteins showed age-dependent activation after the infection as revealed by quantitative expression analysis. Two cell death-associated proteins, autophagy 5-like (Atg5L) and apoptosis-inducing factor (AIF), in addition to caspase, are identified from the infected integumental epithelium through mass spectrometric analysis. Composite cellular profile showed initial autophagy, intermediate endoplasmic reticulum degranulation and deformed nucleus as well as later DNA fragmentation indicating apoptosis. Infection of the commercially important silkworm, Bombyx mori by a tachnid parasitoid, Exorista bombycis induced activation of genes and cellular responses associated with apoptosis in integumental epithelial cells. ![]()
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